Air distance from Milan, Italy to Cayenne, French Guiana is 4617.9 Miles (7431.7 Kilometers / 4010.1 Nautical Miles).
Flight duration time from Milan to Cayenne is 9 hrs, 35 mins. This is the In-The-Air flight time. You should also add the taxi time, airport wait times and possible delays due to bad weather, etc. for the total flight duration time.