Air distance from Santo Domingo, Dominican Republic to Rome, Italy is 4976.6 Miles (8009 Kilometers / 4321.7 Nautical Miles).
Flight duration time from Santo Domingo to Rome is 10 hrs, 20 mins. This is the In-The-Air flight time. You should also add the taxi time, airport wait times and possible delays due to bad weather, etc. for the total flight duration time.