Air distance from Santo Domingo, Dominican Republic to Panama, Panama is 935.6 Miles (1505.7 Kilometers / 812.5 Nautical Miles).
Flight duration time from Santo Domingo to Panama is 2 hrs, 5 mins. This is the In-The-Air flight time. You should also add the taxi time, airport wait times and possible delays due to bad weather, etc. for the total flight duration time.