Air distance from Santo Domingo, Dominican Republic to Bissau, Guinea Bissau is 3638.7 Miles (5855.9 Kilometers / 3159.8 Nautical Miles).
Flight duration time from Santo Domingo to Bissau is 7 hrs, 33 mins. This is the In-The-Air flight time. You should also add the taxi time, airport wait times and possible delays due to bad weather, etc. for the total flight duration time.