Air distance from Orlando, USA to Sao Tome, Sao Tome And Principe is 6069.2 Miles (9767.5 Kilometers / 5270.5 Nautical Miles).
Flight duration time from Orlando to Sao Tome is 12 hrs, 36 mins. This is the In-The-Air flight time. You should also add the taxi time, airport wait times and possible delays due to bad weather, etc. for the total flight duration time.