Air distance from Orlando, USA to Cayenne, French Guiana is 2514.2 Miles (4046.2 Kilometers / 2183.3 Nautical Miles).
Flight duration time from Orlando to Cayenne is 5 hrs, 13 mins. This is the In-The-Air flight time. You should also add the taxi time, airport wait times and possible delays due to bad weather, etc. for the total flight duration time.